Eye fatigue is typically related to eye strain (too much time spent on the computer, reading, near work, etc.) as well as dry eye syndrome. Increased "screen time" is associated with decreased blinking. A person typically blinks about 17 times per minute. This is reduced to 12-15 blinks per minute when looking at a computer screen. Fewer blinks leads to increased tear evaporation and resulting dry, irritated eyes.
How Can I Reduce Eye Fatigue?
20/20/20 Rule: For every 20 minutes looking at a computer/near device, look at a target 20 feet away and blink 20 times to reduce eye strain and dryness.
Consider using artificial tears 1-2 times per day or during long stretches of viewing a computer screen.